Design and Synthesis of C-Terminal Modified Cyclic Peptides as VEGFR1 Antagonists
نویسندگان
چکیده
منابع مشابه
Design and synthesis of C-terminal modified cyclic peptides as VEGFR1 antagonists.
Previously designed cyclic peptide antagonist c[YYDEGLEE]-NH2 disrupts the interaction between vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). It represents a promising tool in the fight against cancer and age-related macular degeneration. We described in this paper the optimization of the lead peptide by C-terminal modification. A new strategy for the synthesis of cyclic ...
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ژورنال
عنوان ژورنال: Molecules
سال: 2014
ISSN: 1420-3049
DOI: 10.3390/molecules191015391